CEFTAROLINE PACKAGE INSERT PDF

For Injection: Teflaro is supplied as mg or mg of sterile ceftaroline fosamil powder in single-dose, 20 mL clear glass. There is minimal potential for drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal . To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEFLARO and other antibacterial drugs, TEFLARO should be used to.

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TEFLARO® (ceftaroline fosamil) Dosing Information

Company contact details Pfizer Limited. For the full list of excipients, see section 6.

Direct antiglobulin test Coombs test seroconversion and potential risk of haemolytic anaemia The development of a positive direct antiglobulin test DAGT may occur during treatment with cephalosporins. Following administration throughout pregnancy and lactation in the rat, there was no effect on pup birth weight or growth, although minor changes in foetal weight and delayed ossification of the interparietal bone were observed when ceftaroline fosamil was administered during organogenesis see section 5.

ceftariline

ABSSSI & CABP IV Therapy | TEFLARO® (ceftaroline fosamil)

I prefer to be contacted by: Patients with pre-existing seizure ceftarokine Seizures have occurred in toxicology studies at times human ceftaroline C max levels see section 5.

The effects of ceftarolije fosamil on fertility on humans have not been studied. TEFLARO is also indicated in adult and pediatric patients 2 months of age and older for the treatment of community-acquired bacterial pneumonia CABP caused by susceptible isolates of the following Gram-positive and Gram-negative microorganisms: The mean terminal elimination half-life of ceftaroline in healthy adults is approximately 2.

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J01DI02 The active moiety after Zinforo administration is ceftaroline. However, when ceftaroline was administered throughout pregnancy and lactation, there was no effect on pup weight or growth.

The development of a positive direct antiglobulin test DAGT may occur during treatment with cephalosporins. There is minimal potential for drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal secretion; and drugs that may alter renal blood flow.

It is unknown whether ceftaroline fosamil or ceftaroline is excreted in human milk. Continue typing to refine. Each vial is for single use only. Ceftaroline fosamil and ceftaroline were clastogenic in an in vitro chromosomal aberration assay, however there was no evidence of mutagenic activity in an Ames test, mouse lymphoma and unscheduled DNA synthesis assay. In vitro studies have not demonstrated any antagonism between ceftaroline in combination with other commonly used antibacterial agents e.

Interaction with other antibacterial agents In vitro studies have not demonstrated any antagonism between ceftaroline in combination with other commonly used antibacterial agents e. Treatment of overdose should follow standard medical practice. Please review Indications and Usage before proceeding.

By continuing, you are confirming that you have read the Indications and Usage. Back to packagr Pfizer Limited contact details.

Zinforo 600 mg powder for concentrate for solution for infusion

Streptococcus pneumoniae including cases with concurrent bacteremiaStaphylococcus aureus methicillin-susceptible isolates onlyHaemophilus influenzaeKlebsiella pneumoniaeKlebsiella oxytocaand Escherichia coli. Zinforo mg powder cefttaroline concentrate for solution for infusion. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

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The total time interval between starting reconstitution and completing preparation of the intravenous infusion should not exceed 30 minutes.

Ceftaroline administration to pregnant rabbits resulted in an increased foetal incidence of angulated hyoid alae, a common skeletal variation in rabbit fetuses, at exposures similar to those observed clinically. Antibacterial-associated colitis and pseudomembranous colitis have been reported with ceftaroline fosamil and may range in severity from mild to life threatening.

Duration of treatment days. The cysts involved a small portion of the kidney and ocurred in the absence of significant changes in either renal isert or urinary parameters. Any unused medicinal product or waste material should be disposed of in accordance with local requirements.

Ceftaroline fosamil prodrug is converted into the active ceftaroline in plasma by phosphatase enzymes and concentrations of the prodrug are measurable in plasma primarily during intravenous infusion. This site is intended for U. Infusion volumes for paediatric patients will vary according to the weight of the child. This site uses cookies.

Hypersensitivity to the cephalosporin class of antibacterials. In vitro susceptibility data are intended for healthcare professionals only.