CEFTAROLINE PACKAGE INSERT PDF

For Injection: Teflaro is supplied as mg or mg of sterile ceftaroline fosamil powder in single-dose, 20 mL clear glass. There is minimal potential for drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal . To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEFLARO and other antibacterial drugs, TEFLARO should be used to.

Author: Tygorn Malkree
Country: Sri Lanka
Language: English (Spanish)
Genre: Software
Published (Last): 17 September 2004
Pages: 339
PDF File Size: 7.23 Mb
ePub File Size: 17.62 Mb
ISBN: 293-3-95304-173-5
Downloads: 55490
Price: Free* [*Free Regsitration Required]
Uploader: Dulmaran

ceftarolie Hypersensitivity to the active substance or to any of the excipients listed in section 6. Appropriate specimens for microbiological examination should be obtained in order to isolate and identify the causative pathogens and to determine their susceptibility to ceftaroline.

In vitro results do not necessarily correlate with how the antibiotic will work in people. Ceftaroline is primarily eliminated by the kidneys. Each vial is for single use only. Please confirm that you are a healthcare professional in the United States.

Zinforo 600 mg powder for concentrate for solution for infusion

Arrived in ED with leg wound. Biotransformation Ceftaroline fosamil prodrug is converted into the active ceftaroline in plasma by phosphatase enzymes and concentrations of the isert are measurable in plasma primarily during intravenous infusion.

Antibacterial-associated colitis and pseudomembranous colitis have been reported with ceftaroline fosamil and may range in severity from mild to life threatening. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. Antibacterials for systemic use, other cephalosporins and penems, ATC code: Therefore, interactions of ceftaroline with medicinal products that are substrates or inhibitors e. Reproductive toxicology Overall, no adverse effects on fertility or post-natal development were observed in the rat at up to 5 times the observed clinical exposure.

  DUAL MANDATE LUGARD PDF

ABSSSI & CABP IV Therapy | TEFLARO® (ceftaroline fosamil)

Each vial contains ceftaroline fosamil acetic acid solvate monohydrate equivalent to mg ceftaroline fosamil. Preferred Contact is required Phone. The development of a positive direct antiglobulin test DAGT may occur during treatment with cephalosporins. Animal studies with ceftaroline fosamil do not indicate harmful effects with respect to fertility see section 5.

However, the possibility that haemolytic anaemia may occur in association with cephalosporins including Zinforo treatment cannot be ruled out. Increased flexibility of infusion time Questions to consider What impact could the 5-minute infusion have on the daily management of these infections in your hospital? The pwckage was the primary target organ of toxicity in both the monkey and ceftarollne.

As a result, minimum inhibitory concentrations MICs of ceftaroline against a proportion of these organisms tested fall into the susceptible range see Resistance section below. Please confirm that you are a healthcare professional in cwftaroline United States.

In vitro results do not necessarily correlate with how the antibiotic will work in people. Renal changes inxert not reversible but were reduced in severity following a 4 week recovery period.

Carcinogenicity studies have not been conducted. Creatinine clearance CrCl estimated using the Cockcroft-Gault formula. Other important toxicologic findings noted in the rat and monkey included histopathologic changes innsert the bladder and spleen. In vitro studies have shown that ceftaroline is bactericidal and able to inhibit bacterial cell wall synthesis in methicillin-resistant Staphylococcus aureus MRSA and penicillin non-susceptible Streptococcus pneumoniae PNSP due to its affinity for the altered penicillin-binding proteins PBPs found in these organisms.

For storage conditions after reconstitution of the medicinal product, see section 6. Reasons for being admitted to the hospital through the emergency department, To email a medicine you must sign up and log in. Virginia, year-old female For illustrative purposes only. As ceftaroline does not appear to undergo significant hepatic metabolism, the systemic clearance of ceftaroline is not expected to be significantly affected by hepatic impairment.

  C200H OMRON MANUAL PDF

pakage Day 4 clinical response of ceftaroline fosamil versus ceftriaxone for community-acquired bacterial pneumonia. Arrived in ED with an abscess with surrounding cellulitis on right thigh.

Hydrolysis of the beta-lactam ring of ceftaroline occurs to form the microbiologically inactive, open-ring metabolite, ceftaroline M Therefore, no dosage adjustment is recommended for patients with hepatic impairment. Hypersensitivity reactions Serious and occasionally fatal hypersensitivity reactions are possible see sections 4. Date of first authorisation: Rash was observed at a common frequency in both the pooled Phase III studies in cSSTI with administration of Zinforo every 12 hours mg administered over 60 minutes every 12 hours and the study in cSSTI with administration every 8 hours mg administered over minutes every 8 hours.

Refers to dosing of adults or adolescents from 12 years and 33 kg with ceftaroline every 8 hours using 2-hour infusions to treat cSSTI see section 4. By continuing to browse the site you are agreeing to our policy on the use of cookies.

Infect Dis Clin Pract. Please also see full Prescribing Information. Histopathologic findings included pigment deposition and inflammation of the tubular epithelium. To bookmark a medicine you must sign up and log in. Mechanism of action In vitro studies have shown that ceftaroline is bactericidal and able to inhibit bacterial cell wall synthesis in methicillin-resistant Staphylococcus aureus MRSA and penicillin non-susceptible Streptococcus pneumoniae PNSP due to its affinity for the altered penicillin-binding proteins PBPs found in these organisms.