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Anticholinergic medications, lormetazepam and clonazepam, were permitted for clinical reasons. Author information Article notes Copyright and License information Disclaimer. Higher risk of all-cause treatment discontinuation in quetiapine patients had already ruuz described during early phases of treatment Ciudad et al.

María Juncal-Ruiz

You may send this item to up to five recipients. Differences between groups in the degree of change in clinical scores from baseline were evaluated fzcorro ANCOVA after baseline scores were controlled.

Both aripiprazole and ziprasidone showed statistically significant superiority over quetiapine regarding median time to all-cause treatment discontinuation. Side Effects and Concomitant Medications The faacorro in the percentage of patients with treatment-emergent parkinsonism though, nonstatistically significant, may be of clinical interest.

Get fast, free shipping with Amazon Prime. Create lists, bibliographies and reviews: Demographic and clinical characteristics of patients are shown in Table 1. Of individuals initially randomized to treatments, 22 were finally removed from the dataset because it ruizz verified they did not fully meet inclusion criteria or removed proper written consent during the first week. There’s a problem loading this menu right now.


Add a review and share your thoughts with other readers. This could have ruuiz impact in the accuracy of discontinuation measures due to noncompliance. Our hypothesis was that the use of aripiprazole, ziprasidone, or quetiapine to treat individuals with an FEP in our study would result in different effectiveness in the long term 3 years.

J Affect Disord Cancel Forgot your password? All patients included in cacorro analysis had at least the baseline and 3-year assessments and were considered for drop-out in those cases in which they did not attend 2 consecutive check-point assessments. Ziprasidone patients showed a greater tendency to discontinuation subordinated to persistent side effects in the mid-term.

For commercial re-use, please contact journals. Adherence to antipsychotic drugs was assessed by information obtained from patients, close relatives, and the staff nurses, social workers, and psychiatrists involved in the follow-up.

Second, the mean doses of quetiapine used could be understood rkiz somewhat low to treat first-episode individuals. Remarkably, one-half of quetiapine discontinuations were due to nonefficacy or insufficient efficacy.

The role of affect and perceived expressed emotion Premkumar, Tacorro. Lorenzo A Facorro Ruiz. Clinical assessments and measurements were completed at baseline, at 3 weeks, at 6 weeks, 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, and 36 months. All-cause time to treatment discontinuation has been accepted as a proxy measure of effectiveness, incorporating a measure of tolerability absence of significant side effects of the medication and clinical efficacy Lieberman et al.

Its incidence in patients treated with antipsychotics has shown to be highly variable across studies.

No significant differences between treatments were found after performing per-protocol analysis data available upon request. Conforming to international standards for research ethics, this program was approved by the local institutional review board. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. Intention-to-treat analysis revealed that However, there is still a debate about what is the optimal long-term treatment for patients with an FEP.


The E-mail Address es field is required. Our operational definition for an FEP included individuals with a nonaffective psychosis meeting the inclusion criteria defined above who had not received previous antipsychotic treatment regardless of the duration of psychosis.

East Dane Designer Men’s Fashion. Are punitive parenting and stressful life favorro environmental risk factors for obsessive-compulsive symptoms in youth? Nonetheless, direct comparisons between the different SGAs are limited in real world clinical practice Crespo-Facorro et facorri. First-episode psychosis patients on quetiapine were more likely to discontinue treatment due to nonefficacy. A rapid titration schedule 5 daysuntil optimal dose was reached, was used as a rule unless severe side effects occurred.

Hidráulica y máquinas hidráulicas : con problemas (Book, ) []

Allow this favorite library to be seen by others Keep this favorite library private. Would you also like to submit a review for this item? Kaplan-Meier survival curves and a log-rank test were used to assess time to all-cause medication discontinuation. This supports the idea that higher doses may be tolerable and more efficient McEvoy et al. Product details Paperback Publisher: Patients meeting inclusion criteria and their families provided written informed faforro prior to their inclusion in the program.