Descriptor Portuguese: Hipofosfatemia Familiar. Synonyms English: Diabetes, Phosphate Familial Hypophosphatemia Hyperphosphaturia Phosphate Diabetes. [] Hipofosfatemia familiar Nefrocalcinose Nefrolitíase Osteomalácia Raquitismo Raquitismo hipofosfatêmico familiar Tomografia. Meanings of “hipofosfatemia” in English Spanish Dictionary: 1 result(s) Medicine. 1, Medicine, hipofosfatemia familiar · familial hypophosphatemia.

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Hypercalcemia is a common underdiagnosed metabolic abnormality, since it is frequently asymptomatic. HPT and malignant humoral hypercalcemia share some similarities such as: However, patients with hypercalcemia associated with malignancy are usually clinically very ill with mestatasis in multiple organs.

The intact PTH iPTH serum measurement is very important for definitive diagnosis, since iPTH is elevated or normal in primary hyperparathyroidism and supressed in malignancies. Hypercalcemia in malignancies may be due to humoral factors secreted by tumors that act on target organs and change normal calcium homeostasis. Also, local factors secreted by tumors in bone, either metastatic or hematological, may stimulate osteoclastic bone resorption.

The parathyroid hormone-related protein PTHrP is responsible for the majority cases of hypercalcemia associated to solid tumors. Other factors like interleukin-6, tumoral growth factor, tumoral necrosis factor and interleukin-1 can modulate the end-organ effects of PTHrP and in some tumors they can directly stimulate the osteoclasts such as in the case of multiple myeloma. Hypercalcemia can less frequently be associated with some endocrine diseases like thyrotoxicosis, pheochromocytoma, Addison’s disease and multiple endocrine neoplasia types I and IIA.

Some drugs may cause this metabolic abnormality, mainly vitamin D, thiazide diuretics, and lithium. The differential diagnosis of hypercalcemias is essencial for the appropriate treatment of this metabolic abnormality. Com a descoberta do PTHrP, este tem sido implicado na maioria destes casos. Considerando as causas incomuns de hipercalcemia, devemos citar: A hipercalcemia pode manifestar-se dentro de dias a semanas de repouso no leito. Postgraduate Medicine ; 5: Acute management of hypercalcemia due to parathyroid hormone and parathyroid hormone-related protein.

The investigation hipofofsatemia hypercalcemia. J Clin Pathol ; Curr Ther Endocrinol Metab ;6: Endocr Rev ;19 1: Hypercalcemia in patients with cancer: Eur J Surg Oncol ;24 2: Martin TJ, Grill V. Clin Endocrinol ; Am J Med ; Eur J Cancer ; Hypercalcemia in hematological malignancies and in solid tumors associated with extensive localized bone destruction.


Production of lymphotoxin, a bone-resorbing cytokine by cultured human myeloma cells. N Engl J Med ; Parathyroid hormonerelated protein purified from a human lung cancer cell line. Identification of a novel J Biol Chem ; Parathyroid hormone-like protein from human renal carcinoma cells.

Structural and bipofosfatemia homology with parathyroid hormone. J Clin Invest ; A parathyroid hormone-related protein implicated in maligant hypercalcemia: Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: Similarity of synthetic peptide from human tumor to parathyroid in vivo and in vitro.

Parathyroid hormone-like peptide in normal and neoplastic human endocrine tissues. J Clin Endocrinol Metab ; J Bone Miner Res hippofosfatemia A case of pheochromocytoma producing parathyroid hormone-related protein and presenting with hypercalcemia.

The humoral hypercalcemia of benignancy.

A newly appreciated syndrome. Am J Clin Pathol ; 4: Tumor necrosis factor enhances parathyroid hormone-related protein PTHrP -induced hypercalcemia and bone resorption without inhibiting bone formation in vivo. Cancer Res ; Stimulation by parathyroid hormone-related protein and transforming growth factor a of phosphate transport in osteoblast-like cells.

J Bone Miner Res ;6: Effect of transforming growth factor a and parathyroid hormone-related protein on phosphate transport in renal cells. Am J Physiol ; Inhibition by human interleukin-1 of parathyfoid hormone-related peptide effects on renal calcium and phosphorus metabolism in the rat. Parathyroid hormone-related peptide shares features with members of early response gene family: Regulation of parathyroid hormone-related peptide production in normal human mammary epithelial cells in vitro.

J Pathol ; Alterations in transforming growth factor-alpha and -beta production and cell responsiveness during the progression of MCF-7 human breast cancer cells to estrogen-autonomous growth.

hipofosfatemia familiar pdf

Transforming growth factor beta secretion from primary breast cancer fibroblasts. Mol Cell Endocrinol ;; Transforming growth factor b increases stability of parathyroid hormone-related protein messenger RNA. J Bone Miner Res ;7 S1: Effects on transforming growth factor-b on parathyroid hormone-related protein production and ribonucleic acid expression by a squamous carcinoma cell hipofosatemia in vitro.

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Transforming factor b stimulation of parathyroid hormone-related protein PTHrP: Mol Cell Endocrinol ; Calcitriol production in hypercalcemic and normocalcemic patients with non-Hodgkin lynfoma.

Ann Intern Med ; Hypercalcemia and elevated 1,dihydroxyvitamin D levels in a patient with end-stage renal disease and actve tuberculosis. N Eng J Med ; Vitamin D conversion by sarcoid lymph node homogenate. Ectopic production of parathyroid hormone by small cell lung cancer in a patient with hyper-calcemia.

Hypercalcemia and ectopic secretion of parathyroid hormone by ovarian carcinoma with rearrangement of the gene for parathyroid hormone. Production of parathyroid hipofosgatemia by a malignant non-parathyroid tumor in a hypercalcemic patient. A thymoma as a cause of true ectopic hyperparathyroidism.

Multiple endocrine neoplasia type I. Basic and Clinical Concepts.


Raven Press, New York Multiple endocrine neoplasia type II. Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: A clinically and genetically distinct syndrome. Hereditary hyperparathyroidism-jaw tumor syndrome: The endocrine tumor gene HRPT2 maps to chromosome 1qq Am J Hum Genet ; Familial isolated primary hyperparathyroidism.

J Familira Miner Res ;7 suppl 1: Autosomal recessive inheritance of familial hyperparathyroidism. Coexisting hyperparathyroidism with thyreotoxicosis.

J Endocrinol Invest ; Hyperthyroidism with coexisting hyperparathyroidism. Am J Surg ; Concomitant Graves disease and primary hyperparathyroidism: Biochemical findings in sarcoidosis. Isolation and structural identification of 1,dihydroxyvitamin D3 produced by cultured hipocosfatemia macrophages in sarcoidosis.

Characterization of la hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis.

Raquitismo e osteomalácia hipofosfatêmicos de origem genética mediados por FGF

J Exp Med ; Adams JS, Diz MM, Sharma OP, Effective reduction in the serum 1,dihydroxyvitamin D and calcium concentration in sarcoidosis-associated hypercalcemia with short-course chloroquine therapy. Ketoconazole decreases the serum 1,dihydroxyvitamin D and calcium concentration in sarcoidosis-associated hypercalcemia.

Familial hypocalciuric hypercalcemia fajiliar neonatal severe hyperparathyroidism: Effects of mutant gene dosage and phenotype.

Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuric after induction of hypoparathyroidism.